| Product Name | p70 S6K beta (phospho Thr389) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to p70 S6K beta (phospho Thr389)p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. P70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5’oligopyrimidine tract mRNAs. A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the N-terminus that encode a nuclear localizing signal. Both isoforms lie on a mitogen-activated signaling pathway downstream of phosphoinositide 3 kinase (PI3K) and the target of rapamycin FRAP/mTOR, and distinct from the Ras/MAP kinase cascade. |
| Modification | p-Thr389 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects p70 S6 kinase only when phosphorylated at Thr389.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | p70-alpha p70S6k p70-S6K 2 p70 S6 kinase beta p70S6K 2 S6 kinase-related kinase phosphop70 S6 Kinase (pThr389) p70alpha phospho p70 S6 Kinase (pThr389) phospho-p70 S6 Kinase (pThr389) S6Kbeta2 S6K2 S6Kbeta Ribosomal protein S6 ki S6 kinasere |
|---|---|
| Target | p70 S6K beta (phospho Thr389) |
| Tissue Specificity | This antibody is specific for p70 S6 Kinase (phospho Thr389). |
| Application Notes | Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects p70 S6 kinase only when phosphorylated at Thr389.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20ºC. For long-term storage, aliquot and freeze at -70ºC. Avoid repeated freeze/defrost cycles |
| Storage Buffer | PBS (pH 7.2) containing 30% glycerol, 0.5% BSA, 0.01% thimerosal |
