Rabbit polyclonal antibody to PAI-1PAI-1 (plasminogen activator inhibitor-1) is originally cloned from human endothelial cell (ref 1,2) and rat hepatica cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI-1 inhibits both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). High PAI-1 levels are associated with an increased risk of thromboembolic disease while PAI-1 deficiency may represent an inherited autosomal recessive bleeding disorder.
Immunogen
Recombinant full length protein (Rat).
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
WB: Use at a dilution of 1/1000. Optimal dilutions/concentrations should be determined by the end user.:
Species Reactivity
Rat
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Protein A
Target Information
Gene Synonyms
PAI1A Pai1 Pai1aa Planh RATPAI1A
Target
PAI-1
Cellular Localization
Secreted
Application
Application
Rat PAI-1 detected by Western blot on Day 3 in a glomerular nephritis model
Application Notes
WB: Use at a dilution of 1/1000. Optimal dilutions/concentrations should be determined by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.