Rabbit polyclonal antibody to PBRPBR (Peripheral-type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid-producing tissues and is found in association with a 34 kDa voltage-dependent anion channel protein (VDAC). PBR is involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHCWB
Western blot analysis (0.5-4 µg/ml) and Immunohistochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually.:
Species Reactivity
HumanMouseRat
Concentration
0.2mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
peripheral-type benzodiazepine receptor
Target
PBR
Tissue Specificity
This antibody is specific for PBR.
Application
Application
Western blot analysis of PBR expression using:
Lane 1: Jurkat cell lysate
Lane 2: Recombinant PBR
Lane 3: Rat kidney tissue lysate
Application
Western blot analysis of PBR expression in rat kidney tissue lysate
Application Notes
Western blot analysis (0.5-4 µg/ml) and Immunohistochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually.:
Additional Information
Form
Liquid
Storage Instructions
The antibody solution should be gently mixed before use. Stored at -20 °C for future use.