| Product Name | PC1/3 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to PC1/3The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010] |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blotting: 1/500 - 1/1000 Optimal dilution / concentration should be determined by the end user.: |
|
| Species Reactivity | HumanMonkeyRat |
| Concentration | 1mg/ml |
| Purification | Serum |
| Gene Synonyms | PC3 NEC1 PCSK1 SPC3 BMIQ12 |
|---|---|
| Target | PC1 + PC3 |
| Tissue Specificity | This antibody recognizes the peptide enzyme designated neuroendocrine convertase 1 and also known as PC1/3 and NEC1. |
| Application Notes | Western Blotting: 1/500 - 1/1000 Optimal dilution / concentration should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | 0.09%Sodium Azide |
