Rabbit Polyclonal antibody to PDGF Receptor betaPDGF Receptor beta encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Immunogen
Peptide sequence around aa.749~753 (V-D-Y-V-P) derived from Human PDGFRb.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
WB
Suggested starting dilutions are as follows. WB: 1:500~1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Species Reactivity
HumanMouseRat
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
CD140B JTK12 PDGFR PDGFR1 PDGFRB PDGFR-beta platelet-derived growth factor receptor 1 PDGF-R-beta platelet-derived growth factor receptor beta beta-type platelet-derived growth factor receptor CD140 antigen-like family member B platelet-derived
Target
PDGF Receptor beta
Molecular Weight(MW)
190 (note)
Application
Application
Western blot analysis of extracts from HepG2 cells using PDGF Receptor beta Antibody .
Application
Western blot analysis of extracts from HepG2 cells using PDGF Receptor b(Ab-751) Antibody
Application Notes
Suggested starting dilutions are as follows. WB: 1:500~1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.