Rabbit polyclonal antibody to PDGF Receptor betaThis gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide corresponding to the extracellular domain of human PDGF receptor beta conjugated to Keyhole Limpet Hemocyanin.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-P
Immunohistology - Paraffin: Max Dilution 20 ug/ml Optimal dilution / concentration should be determined by the end user.:
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
CD140B PDGFR JTK12 PDGFRB IBGC4 PDGFR1 PDGFR-1
Target
CD140B
Tissue Specificity
This antibody recognizes PDGF Receptor beta.
Application
Application
IHC-P analysis of human renal cortex tissue using PDGF Receptor beta antibody.
Application Notes
Immunohistology - Paraffin: Max Dilution 20 ug/ml Optimal dilution / concentration should be determined by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.