| Product Name | PGCD antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to PGCDIn response to G-protein couples receptor stimulation, the cGMP can be produced from GTP by either cytoplasmic, soluble guanylate cyclase (sGC) are heterodimers ('N & 'O polypeptide chains), that are stimulated by nitric oxide and carbon monoxide or by particulate membrane-bound guanylyl cyclases which are activated by a complex mechanism by natriuretic peptides. Particulate GC (PGCs) have 7 different isoforms, PGC-A through PGC-G and are expressed in most tissues in isoform specific manner. There is significant structural homology among various PGCs, there is a large N-terminal extracellular domain (ECD), a single TMD and a large intracellular domain with protein kinase activity (KLD), a C-terminal catalytic domain (CD) and in between is a dimmerization domain (DD). The particulate GC-D, also known as olfactory gunylate cyclas, is specifically expressed in a subpopulation of olfactory sensory neurons. |
| Immunogen | Synthetic peptide (Human) (C terminal). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: Use at a dilution of 1/500. Detects a band of approximately 135 kDa (predicted molecular weight: 120 kDa). A ~135 kDa band was seen using peptide controls and also when using rat olfactory bulb homogenates. Optimal dilutions/concentrations should be determined by the end user.: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CORD5 CORD6 CYGD GUC1A4 GUC2D LCA LCA1 RCD2 RETGC-1 ROS-GC1 ROSGC retGC RETGC 1 ROS GC1 RETGC1 ROSGC1 |
|---|---|
| Target | PGCD |
| Cellular Localization | Plasma membrane |
| Application Notes | WB: Use at a dilution of 1/500. Detects a band of approximately 135 kDa (predicted molecular weight: 120 kDa). A ~135 kDa band was seen using peptide controls and also when using rat olfactory bulb homogenates. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Stabilization buffer |
