Application
Western blot analysis of PICALM in EL4 cell lysate with PICALM antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.Application
Immunofluorescence of PICALM in human brain tissue with PICALM antibody at 20 μg/mL.Application
Western blot analysis of PICALM in EL4 cell lysate with PICALM antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Product Name | PICALM antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to PICALMPICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFWB |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | LAP, CALM, CLTH, Phosphatidylinositol-binding clathrin assembly protein, PICALM, Phosphatidylinositolbinding clathrin assembly protein |
|---|---|
| Target | PICALM |
| Tissue Specificity | This antibody is specific for PICALM |
Application
Western blot analysis of PICALM in EL4 cell lysate with PICALM antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Application
Immunofluorescence of PICALM in human brain tissue with PICALM antibody at 20 μg/mL.
Application
Western blot analysis of PICALM in EL4 cell lysate with PICALM antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
