| Product Name | PKA RIIb (phospho Ser114) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to PKA RIIb (phospho Ser114)cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase | which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adi |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human PKA regulatory II subunit that contains serine 114. The sequence is conserved in mouse | rat | cow and rabbit. |
| Modification | p-Ser114 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1:1000 | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | RII BETA , PRKAR2B , PRKAR2 , protein kinase cAMP-dependent type II regulatory subunit beta |
|---|---|
| Target | PKA RIIb (phospho Ser114) |
| Application Notes | WB: 1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at −20°C |
| Storage Buffer | Dulbecco's phosphate buffered saline (without Mg2+ and Ca2+) | pH 7.3 (+/-0.1) | 50% glycerol | with 1.0 mg/mL BSA (IgG | protease free) as a carrier and 0.05% sodium azide. |
