| Product Name | PKR (phospho Thr451) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to PKR (phospho Thr451)The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| Modification | p-Thr451 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| Suggested starting dilutions are as follows. IHC: 1:50-1:100. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | Phospho PKR (Thr451) , PKR T451 phospho , PKR phospho T451 , PKR (Phospho Thr451) , EIF2AK2 , PRKR , PKR phospho , Phospho PKR (pT451) , PKR phospho Thr451 , phospho PKR , phospho PKR Thr451 , PKR (pT451) , phospho PKR T451 , Phospho PKR (pThr |
|---|---|
| Target | PKR |
| Cellular Localization | Associated with intracytoplasmic membranes. |
| Application Notes | Suggested starting dilutions are as follows. IHC: 1:50-1:100. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS (without Mg2+and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol. |
