| Product Name | Plasminogen antibody [8E7] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [8E7] to PlasminogenPlasminogen is a plasma protein synthesised mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70 - 200mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism. |
| Immunogen | Full length native protein (purified) (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 8E7 |
| Host Species | Mouse |
| Tested Applications | PurifyELISAIHC-P |
| For AP: Use at an assay dependent dilution. For ELISA: Use at an assay dependent dilution. For IHC-P: Use at an assay dependent dilution. Antigen retrieval is not essential but may optimise staining. Can be used in ELISA with GTX10177 and 10173 (coating). Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Gene Synonyms | DKFZp779M0222 |
|---|---|
| Target | Plasminogen |
| Tissue Specificity | Reacts with human plasminogen and plasmin molecules. |
| Application Notes | For AP: Use at an assay dependent dilution. For ELISA: Use at an assay dependent dilution. For IHC-P: Use at an assay dependent dilution. Antigen retrieval is not essential but may optimise staining. Can be used in ELISA with GTX10177 and 10173 (coating). Optimal dilutions/concentrations should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. |
| Storage Buffer | Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide |
