| Product Name | PLCG1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to PLCG1The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | Synthetic peptide corresponding to the C-terminal residues of human PLC gamma1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IPWB |
| For IP: Use at a dilution of 1:50. For WB: Use at a dilution of 1:1,000. Optimal dilutions/concentrations should be determined by the end user. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | PLCG1, PLC1, PLCgamma1, PLCII, PLC148, PLC-II, NCKAP3, PLC II |
|---|---|
| Target | PLCG1 |
| Tissue Specificity | Recognizes endogenous levels of total human PLC gamma 1 protein. Does not crossreact with PLC gamma 2 |
| Application Notes | For IP: Use at a dilution of 1:50. For WB: Use at a dilution of 1:1,000. Optimal dilutions/concentrations should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA containing 50% glycerol |
