ATP-binding cassette sub-family C member 9, Sulfonylurea receptor 2, ABCC9, SUR2
Product description
The protein encoded by this gene is a member of the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the MRP subfamily which is involved in
multi-drug resistance. This protein is thought to form
ATP-sensitive potassium channels in cardiac, skeletal, and vascular
and non-vascular smooth muscle. Protein structure suggests a role
as the drug-binding channel-modulating subunit of the
extrapancreatic ATP-sensitive potassium channels. No disease has
been associated with this gene thus far. Alternative splicing of
this gene results in several products, two of which result from
differential usage of two terminal exons and one of which results
from exon deletion.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This ABCC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 640-669 amino acids from the Central region of human ABCC9.
Western blot analysis in mouse kidney tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.