Application
Immunohistochemistry staining of ADAM17 in skeletal muscle (formalin-fixed paraffin embedded) tissue using ADAM17 Antibody.| Product Name | ADAM17 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. ADAM17 is a Metallopeptidase M12B type protease. |
| Immunogen | ADAM17 antibody was raised against a synthetic peptide corresponding to C-Terminal residues of ADAM17 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| ADAM17 antibody can be used in Western Blot, and immunohistochemistry starting at 5 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ADAM17 |
|---|---|
| Alternative Names | ADAM17 CD156B CD156b antigen CSVP ADAM 17 NISBD TNF-alpha converting enzyme TNF-alpha convertase TNF-alpha-converting enzyme Snake venom-like protease TACE |
Application
Immunohistochemistry staining of ADAM17 in skeletal muscle (formalin-fixed paraffin embedded) tissue using ADAM17 Antibody.| Application Notes | ADAM17 antibody can be used in Western Blot, and immunohistochemistry starting at 5 μg/mL. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store ADAM17 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.01% sodium azide, 50% glycerol. |
