This gene belongs to the ADAMTS (a disintegrin and
metalloproteinase domain with thrombospondin type-1 motifs) family
of zinc-dependent proteases. ADAMTS proteases are complex secreted
enzymes containing a prometalloprotease domain of the reprolysin
type attached to an ancillary domain with a highly conserved
structure that includes at least one thrombospondin type 1 repeat.
They have been demonstrated to have important roles in connective
tissue organization, coagulation, inflammation, arthritis,
angiogenesis and cell migration. The product of this gene plays a
major role in growth and in skin, lens, and heart development. It
is also a candidate gene for autosomal recessive Weill-Marchesani
syndrome.1) Morales, J., et al. Am. J. Hum. Genet. 85(5):558-568(2009)
Immunogen
This ADAMTS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the N-terminal region of human ADAMTS10.
Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.