| Product Name | Prorenin antibody (Inhibitory) |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Inhibitory Mouse Monoclonal antibody [4B5-E3] to human proreninRenin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq] |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 4B5-E3 |
| Host Species | Mouse |
| Tested Applications | BlockingELISAWB |
| Not yet tested in other applications. Optimal dilutions should be determined experimentally by the researcher.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | FLJ10761 |
|---|---|
| Target | Recognizes amino acid residues 3-43 (MARLGPEWSQPMKR) of the prosegment of prorenin. |
| Cellular Localization | Associated to membranes via binding to ATP6AP2. |
| Light Chain Type | kappa |
| Application Notes | Not yet tested in other applications. Optimal dilutions should be determined experimentally by the researcher.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 |
