Rabbit polyclonal antibody to Protein C (protein C (inactivator of coagulation factors Va and VIIIa))The PROC gene encodes protein C (EC 3.4.21.69), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.[supplied by OMIM]
Immunogen
Recombinant protein encompassing a sequence within the center region of human Protein C. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
*Optimal dilutions/concentrations should be determined by the researcher.
:
Species Reactivity
Human
Predicted Reactivity
Dog, RabbitDog (82%), Rabbit (84%)
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)
Purification
Affinity purified
Target Information
Gene Synonyms
APC antibody PC antibody PROC1 antibody PROC antibody vitamin K-dependent protein C antibody anticoagulant protein C antibody blood coagulation factor XIV antibody autoprothrombin IIA antibody protein C (inactivator of coagulation factors Va and VI
Target
Protein C
Molecular Weight(MW)
52 kDa (note)
Application
Application
Sample (30 ug of whole cell lysate) A: Molt-4 10% SDS PAGE diluted at 1:3000
Positive Control
293T , A431 , H1299 , HeLa , Molt-4 , Raji
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
:
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.