Application
Western blot analysis of Aldh5A1 in human liver tissue lysate with Aldh5A1 antibody at (A) 0.25 and (B) 0.5 μg/mL.| Product Name | Aldh5A1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Aldh5A1 Antibody: SSDH, SSADH, Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1 |
| Product description | Aldh5A1 Antibody: Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.1) Vasiliou V and Pappa A. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. Pharmacology2000; 61:192-8. |
| Immunogen | Aldh5A1 antibody was raised against a 22 amino acid synthetic peptide near the carboxy terminus of the human Aldh5A1. The immunogen is located within the last 50 amino acids of Aldh5A1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| Aldh5A1 antibody can be used for detection of Aldh5A1 by Western blot at 0.25 - 0.5 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ALDH5A1 |
|---|---|
| Alternative Names | Aldh5A1 Antibody: SSDH SSADH Succinate-semialdehyde dehydrogenase mitochondrial Aldehyde dehydrogenase family 5 member A1 |
| Molecular Weight(MW) | Predicted: 60 kDa Observed: 60 kDa |
Application
Western blot analysis of Aldh5A1 in human liver tissue lysate with Aldh5A1 antibody at (A) 0.25 and (B) 0.5 μg/mL.| Positive Control | 1) Cat. No. 1304 - Human Liver Tissue Lysate |
|---|---|
| Application Notes | Aldh5A1 antibody can be used for detection of Aldh5A1 by Western blot at 0.25 - 0.5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Aldh5A1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Aldh5A1 Antibody is supplied in PBS containing 0.02% sodium azide. |
