This gene belongs to the motin family of angiostatin
binding proteins characterized by conserved coiled-coil domains and
C-terminal PDZ binding motifs. The encoded protein is expressed
predominantly in endothelial cells of capillaries as well as larger
vessels of the placenta where it may mediate the inhibitory effect
of angiostatin on tube formation and the migration of endothelial
cells toward growth factors during the formation of new blood
vessels. Alternative splicing results in multiple transcript
variants encoding different isoforms.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This AMOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-312 amino acids from the Central region of human AMOT.
Western Blot at 1:500-1:1000 dilution Lane 1: 293 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 ug per lane.
Application Notes
For WB starting dilution is: 1:500-1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.