| Product Name | Proteinase Inhibitor 9 (PI9) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Proteinase Inhibitor 9 (PI9)Proteinase inhibitor 9 (PI-9, also designated cytoplasmic antiproteinase 3, or CAP3) is a 42 kDa member of the ovalbumin family of serpins that is expressed in placenta, lung and cytotoxic lymphocytes. PI-9 is a potent inhibitor of granzyme B and of granzyme B-mediated apoptosis, and is also an inhibitor of capase-1 and, to a smaller extent, caspase-4 and caspase-8. PI-9 expression is also upregulated in response to inflammatory stimuli. This upregulation protects cells from apoptosis induced by endogenously expressed or released granzyme B, particulary during target cell killing |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 42 kDa human PI-9. Reactivity to other species has not been tested.: |
|
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Protease inhibitor9 ovalbumin type Serpin B9 Serine Cysteine ase Inhibitor CAP3 Cytoplasmic antiase3 PI9 SERPINB9 CAP 3 |
|---|---|
| Target | Proteinase Inhibitor 9 (PI9) |
| Tissue Specificity | This antibody is specific for Proteinase Inhibitor 9 (PI9). |
| Application Notes | Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 42 kDa human PI-9. Reactivity to other species has not been tested.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The antibody solution should be gently mixed before use. Stored at -20 °C for future use. |
| Storage Buffer | PBS (pH 7.2) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal |
