| Product Name | Anthrax PA Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Anthrax PA Antibody : pag, pXO1-110, BXA0164, GBAA_pXO1_0164, Protective antigen, Anthrax toxins translocating protein, PA |
| Product description | Anthrax PA Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.1) Schwartz MN. Recognition and management of anthrax - an update. New Engl. J. Med. 2001; 345:1621-6. |
| Immunogen | Anthrax PA antibody was raised against a synthetic peptide corresponding to 16 amino acids in the middle of the Anthrax protective antigen protein. The immunogen is located within amino acids 300 - 350 of Anthrax PA . |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISA |
| Anthrax PA antibody can be used for the detection of Anthrax PA protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.: |
|
| Species Reactivity | Bacteria |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | pxo1_110 |
|---|---|
| Alternative Names | Anthrax PA Antibody : pag pXO1-110 BXA0164 GBAA_pXO1_0164 Protective antigen Anthrax toxins translocating protein PA |
| Application Notes | Anthrax PA antibody can be used for the detection of Anthrax PA protein in ELISA. It will detect 10 ng of free peptide at 1 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Anthrax PA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Anthrax PA Antibody is supplied in PBS containing 0.02% sodium azide. |
