The annexins are a family of calcium-dependent
phospholipid-binding proteins. Members of the annexin family
contain 4 internal repeat domains, each of which includes a type II
calcium-binding site. The calcium-binding sites are required for
annexins to aggregate and cooperatively bind anionic phospholipids
and extracellular matrix proteins. This gene encodes a divergent
member of the annexin protein family in which all four homologous
type II calcium-binding sites in the conserved tetrad core contain
amino acid substitutions that ablate their function. However,
structural analysis suggests that the conserved putative ion
channel formed by the tetrad core is intact.1) Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Immunogen
This ANXA9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-235 amino acids from the Central region of human ANXA9.
Western blot analysis in WiDr cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.