Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2, Centaurin-delta-1, Cnt-d1, Protein PARX, ARAP2, CENTD1, KIAA0580
Product description
The protein encoded by this gene contains ARF-GAP,
RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology
domains. The protein is a phosphatidylinositol
(3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but
it lacks the predicted catalytic arginine in the RHO-GAP domain and
does not have RHO-GAP activity. The protein associates with focal
adhesions and functions downstream of RhoA to regulate focal
adhesion dynamics.1) Gavicherla, B., et al. Infect. Immun. 78(11):4532-4541(2010)
Immunogen
This ARAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-93 amino acids from the N-terminal region of human ARAP2.
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.