Application
Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.Application
Immunofluorescence of ARMER in Mouse Intestine cells with ARMER antibody at 2 μg/mL.Application
Immunohistochemical staining of human bladder tissue using ARMER antibody at 2 μg/mL.| Product Name | ARMER Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ARMER Antibody: AIP1, ARMER, SPG61, ARL6IP, KIAA0069, ADP-ribosylation factor-like protein 6-interacting protein 1, ARL-6-interacting protein 1 |
| Product description | ARMER Antibody: Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.1) Stellar H. Mechanisms and genes of cellular suicide. Science 1995; 267:1445-9. |
| Immunogen | ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER. The immunogen is located within the last 50 amino acids of ARMER. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| ARMER antibody can be used for detection of ARMER by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 2 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ARL6IP1 |
|---|---|
| Alternative Names | ARMER Antibody: AIP1 ARMER SPG61 ARL6IP KIAA0069 ADP-ribosylation factor-like protein 6-interacting protein 1 ARL-6-interacting protein 1 |
Application
Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.
Application
Immunofluorescence of ARMER in Mouse Intestine cells with ARMER antibody at 2 μg/mL.
Application
Immunohistochemical staining of human bladder tissue using ARMER antibody at 2 μg/mL.| Positive Control | 1) Cat. No. 1408 - Mouse Small Intestine Tissue Lysate |
|---|---|
| Application Notes | ARMER antibody can be used for detection of ARMER by Western blot at 0.5 to 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | ARMER antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | ARMER Antibody is supplied in PBS containing 0.02% sodium azide. |
