V-type proton ATPase subunit C 2, V-ATPase subunit C 2, Vacuolar proton pump subunit C 2, ATP6V1C2
Product description
This gene encodes a component of vacuolar ATPase
(V-ATPase), a multisubunit enzyme that mediates acidification of
eukaryotic intracellular organelles. V-ATPase dependent organelle
acidification is necessary for such intracellular processes as
protein sorting, zymogen activation, receptor-mediated endocytosis,
and synaptic vesicle proton gradient generation. V-ATPase is
composed of a cytosolic V1 domain and a transmembrane V0 domain.
The V1 domain consists of three A,three B, and two G subunits, as
well as a C, D, E, F, and H subunit. The V1 domain contains the ATP
catalytic site. This gene encodes alternate transcriptional splice
variants, encoding different V1 domain C subunit isoforms.1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Immunogen
This ATP6V1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-304 amino acids from the Central region of human ATP6V1C2.
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.