| Product Name | Avian Influenza Nonstructural Protein 1 Antibody |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | Avian Influenza Nonstructural Protein 1 Antibody: |
| Product description | Avian Influenza Nonstructural Protein 1 Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however, it is in birds that all subtypes, including the so-called "avian flu" or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2'-5'OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the anti-viral protein kinase PKR.1) Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003; 289:179-186. |
| Immunogen | Avian Influenza Nonstructural Protein 1 antibody was raised against a synthetic peptide corresponding to 14 amino acids at the carboxy terminus of the Avian Influenza Nonstructural Protein 1 protein. Efforts were made to use relatively conserved regions of |
| Clonality | Polyclonal |
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| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISA |
| Avian Influenza Nonstructural Protein 1 antibody can be used for the detection of the avian influenza nonstructural protein 1 protein from influenza A in ELISA.: |
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| Species Reactivity | Virus |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | Avian Influenza Nonstructural Protein 1 Antibody: |
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| Protein Accession | ABC72653 |
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| Application Notes | Avian Influenza Nonstructural Protein 1 antibody can be used for the detection of the avian influenza nonstructural protein 1 protein from influenza A in ELISA.: |
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| Form | Liquid |
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| Storage Instructions | Avian Influenza Nonstructural Protein 1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Avian Influenza Nonstructural Protein 1 Antibody is supplied in PBS containing 0.02% sodium azide. |
