This gene is a member of the
beta-1,3-galactosyltransferase (beta3GalT) gene family. This family
encodes type II membrane-bound glycoproteins with diverse enzymatic
functions using different donor substrates (UDP-galactose and
UDP-N-acetylglucosamine) and different acceptor sugars
(N-acetylglucosamine, galactose, N-acetylgalactosamine). The
beta3GalT genes are distantly related to the Drosophila Brainiac
gene and have the protein coding sequence contained in a single
exon. The beta3GalT proteins also contain conserved sequences not
found in the beta4GalT or alpha3GalT proteins. The carbohydrate
chains synthesized by these enzymes are designated as type 1,
whereas beta4GalT enzymes synthesize type 2 carbohydrate chains.
The ratio of type 1:type 2 chains changes during embryogenesis. By
sequence similarity, the beta3GalT genes fall into at least two
groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3,
beta3GalT5). This gene encodes a protein that functions in N-linked
glycoprotein glycosylation and shows strict donor substrate
specificity for UDP-galactose.1) Lamesch, P., et al. Genomics 89(3):307-315(2007)
Immunogen
This B3GALT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-422 amino acids from the C-terminal region of human B3GALT2.
Western blot analysis in mouse heart tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.