Application
Immunohistochemistry staining of BARD1 in skin using BARD1 Antibody.Application
Immunohistochemistry staining of BARD1 in skeletal muscle tissue using BARD1 Antibody.| Product Name | BARD1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | BARD1 interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, BARD1 shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. The BARD1 protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. BARD1 may be the target of oncogenic mutations in breast or ovarian cancer. |
| Immunogen | Amino acids 108 to 124 of human BARD1 |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| BARD1 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 10 μg/mL, immunofluorescence, and immunoprecipitation. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | BARD1 |
|---|---|
| Alternative Names | BARD1 BARD-1 BRCA1 associated RING domain 1 |
Application
Immunohistochemistry staining of BARD1 in skin using BARD1 Antibody.
Application
Immunohistochemistry staining of BARD1 in skeletal muscle tissue using BARD1 Antibody.| Application Notes | BARD1 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 10 μg/mL, immunofluorescence, and immunoprecipitation. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | BARD1 antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
