Application
Immunohistochemistry of BOK in human brain tissue with BOK antibody at 5 μg/mL.| Product Name | BOK Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BOK Antibody: BOKL, BCL2L9, Bcl-2-related ovarian killer protein, Bcl-2-like protein 9, hBOK |
| Product description | BOK Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. BOK, a pro-apoptotic Bcl-2 family member, was initially identified in the ovary, and was found to interact with other Bcl-2 family members such as Mcl-1 and Bfl-1. BOK expression is high during early placental development, suggesting that it may also play a role in regulating trophoblast cell proliferation.1) Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7. |
| Immunogen | BOK antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human BOK. The immunogen is located within the first 50 amino acids of BOK. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-P |
| BOK antibody can be used for detection of BOK by immunohistochemistry at 5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | BOK |
|---|---|
| Alternative Names | BOK Antibody: BOKL BCL2L9 Bcl-2-related ovarian killer protein Bcl-2-like protein 9 hBOK |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Rat: (100%) |
| Tissue Specificity | At least three isoforms of BOK are known to exist; this antibody will not detect the smallest isoform. BOK antibody is predicted to not cross-react with other Bcl-2 protein family members |
Application
Immunohistochemistry of BOK in human brain tissue with BOK antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 10-301 - Human Brain Tissue Slide |
|---|---|
| Application Notes | BOK antibody can be used for detection of BOK by immunohistochemistry at 5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | BOK antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | BOK Antibody is supplied in PBS containing 0.02% sodium azide. |
