| Product Name | PSMC5 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to TRIP1The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IPWB |
| Western blotting (1:500 – 1:2500). However, the optimal concentrations should be determined individually. HeLa and NIH3T3 cell lysates can be used as positive controls. The antibody recognizes the TRIP1(SUG1) of human and mouse origins. Reactivity to other species has not been tested.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | PSMC5 SUG1 Tatbinding protein homolog 10 S8 Tat-binding protein homolog 10 p45 Tatbinding protein homolog10 Proteasome (prosome Thyroid Receptor Interactor 1 TRIP-1 TRIP1 ATPase p45/SUG macropain) 26S Subunit TBP10 Thyroid Receptor Interacto |
|---|---|
| Target | TRIP1 |
| Tissue Specificity | This antibody is specific for TRIP1. |
| Application Notes | Western blotting (1:500 – 1:2500). However, the optimal concentrations should be determined individually. HeLa and NIH3T3 cell lysates can be used as positive controls. The antibody recognizes the TRIP1(SUG1) of human and mouse origins. Reactivity to other species has not been tested.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The antibody solution should be gently mixed before use. Stored at -20 °C for future use. |
| Storage Buffer | PBS (pH 7.2) containing 30% glycerol, 1% BSA and 0.02% thimerosal |
