Confocal immunofluorescent analysis of C1QC Antibody with WiDr cell followed by Alexa Fluor? 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
This gene encodes a major constituent of the human
complement subcomponent C1q. C1q associates with C1r and C1s in
order to yield the first component of the serum complement system.
A deficiency in C1q has been associated with lupus erythematosus
and glomerulonephritis. C1q is composed of 18 polypeptide chains:
six A-chains, six B-chains, and six C-chains. Each chain contains a
collagen-like region located near the N-terminus, and a C-terminal
globular region. The A-, B-, and C-chains are arranged in the order
A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of
human complement subcomponent C1q. Alternatively spliced transcript
variants that encode the same protein have been found for this
gene.1) Fraser, D.A., et al. J. Immunol. 185(7):3932-3939(2010)
Immunogen
This C1QC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the Central region of human C1QC.
Key Feature
Clonality
Polyclonal
Isotype
Ig
Host Species
Rabbit
Tested Applications
IFIHC-PWB
For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50 For FACS starting dilution is: 1:10~50 For IF starting dilution is: 1:10~50
Confocal immunofluorescent analysis of C1QC Antibody with WiDr cell followed by Alexa Fluor? 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Application Notes
For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50 For FACS starting dilution is: 1:10~50 For IF starting dilution is: 1:10~50
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.