Application
Western blot analysis of CaBP8 in 3T3 cell lysate with CaBP8 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | CaBP8 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | CaBP8 Antibody: Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP8, contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.1) Sokal I, Li N, Verlinde CL, et al. Ca2+-binding proteins in the retina: from discovery to etiology of human disease. Biochim. Biophys. Acta.2000; 1498: 233-51. |
| Immunogen | CaBP8 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CaBP8. The immunogen is located within the first 50 amino acids of CaBP8. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| CaBP8 antibody can be used for detection of CaBP8 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CALN1 |
|---|---|
| Alternative Names | CaBP8 Antibody: CABP8 CABP8 Calcium-binding protein 8 Calneuron I CaBP8 |
Application
Western blot analysis of CaBP8 in 3T3 cell lysate with CaBP8 antibody at (A) 1 and (B) 2 μg/mL.| Application Notes | CaBP8 antibody can be used for detection of CaBP8 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | CaBP8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | CaBP8 Antibody is supplied in PBS containing 0.02% sodium azide. |
