Application
Immunofluorescence of CALHM1 in Rat Liver cells with CALHM1 antibody at 20 μg/mL.Application
Immunohistochemistry of CALHM1 in rat liver tissue with CALHM1 antibody at 5 μg/mL.Application
Western blot analysis of CALHM1 in rat liver tissue lysate with CALHM1 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | CALHM1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | CALHM1 Antibody: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.1) Mattson MP. Pathways towards and away from Alzheimer’s disease. Nature2004; 430:631-9. |
| Immunogen | CALHM1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1. The immunogen is located within amino acids 60 - 110 of CALHM1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| CALHM1 antibody can be used for detection of CALHM1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CALHM1 |
|---|---|
| Alternative Names | CALHM1 Antibody: FAM26C FAM26C Calcium homeostasis modulator protein 1 Protein FAM26C |
| Entrez Gene | 255022 |
|---|---|
| Protein Accession | NP_001001412 |
Application
Immunofluorescence of CALHM1 in Rat Liver cells with CALHM1 antibody at 20 μg/mL.
Application
Immunohistochemistry of CALHM1 in rat liver tissue with CALHM1 antibody at 5 μg/mL.
Application
Western blot analysis of CALHM1 in rat liver tissue lysate with CALHM1 antibody at (A) 1 and (B) 2 μg/mL.| Application Notes | CALHM1 antibody can be used for detection of CALHM1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | CALHM1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | CALHM1 Antibody is supplied in PBS containing 0.02% sodium azide. |
