Application
Antibody used in WB on Human Liver at 0.2-1 ug/ml.| Product Name | CAMLG Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.1) Nagano, J., (2005) Biochem. Biophys. Res. Commun. 338 (2), 880-889. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CAMLG. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| CAMLG antibody can be used for detection of CAMLG by ELISA at 1:12500. CAMLG antibody can be used for detection of CAMLG by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CAMLG |
|---|---|
| Alternative Names | CAMLG CAML MGC163197 |
| Molecular Weight(MW) | 33 kDa |
Application
Antibody used in WB on Human Liver at 0.2-1 ug/ml.| Application Notes | CAMLG antibody can be used for detection of CAMLG by ELISA at 1:12500. CAMLG antibody can be used for detection of CAMLG by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
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| Form | Liquid |
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| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store CAMLG antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
