Application
Immunohistochemistry of CARMA2 in human placenta tissue with CARMA2 antibody at 5 μg/mL.| Product Name | CARMA2 Antibody |
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| Antibody Type | Primary Antibodies |
| Product description | CARMA2 Antibody: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activated NF-κB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-κB activation and endoplasmic reticulum stress-induced cell death.1) Fanning AS and Anderson JM. Protein modules as organizers of membrane structure. Curr. Opin. Cell Biol. 1999; 11:432-9. |
| Immunogen | CARMA2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human CARMA2. The immunogen is located within the last 50 amino acids of CARMA2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-P |
| CARMA2 antibody can be used for detection of CARMA2 by immunohistochemistry at 5 μg/mL.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CARD14 |
|---|---|
| Alternative Names | CARMA2 Antibody: PRP PSS1 BIMP2 CARMA2 PSORS2 Caspase recruitment domain-containing protein 14 CARD-containing MAGUK protein 2 Carma 2 |
Application
Immunohistochemistry of CARMA2 in human placenta tissue with CARMA2 antibody at 5 μg/mL.| Application Notes | CARMA2 antibody can be used for detection of CARMA2 by immunohistochemistry at 5 μg/mL.: |
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| Form | Liquid |
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| Storage Instructions | CARMA2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | CARMA2 Antibody is supplied in PBS containing 0.02% sodium azide. |
