The protein encoded by this gene specifies the cardiac
muscle family member of the calsequestrin family. Calsequestrin is
localized to the sarcoplasmic reticulum in cardiac and slow
skeletal muscle cells. The protein is a calcium binding protein
that stores calcium for muscle function. Mutations in this gene
cause stress-induced polymorphic ventricular tachycardia, also
referred to as catecholaminergic polymorphic ventricular
tachycardia 2 (CPVT2), a disease characterized by bidirectional
ventricular tachycardia that may lead to cardiac arrest. [provided
by RefSeq].1) Kirchhefer, U., et al. J. Mol. Cell. Cardiol. 49(1):95-105(2010)
Immunogen
This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2.
Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.