Application
Immunofluorescence of CCDC106 in rat brain tissue with CCDC106 antibody at 20 μg/mL.Application
Immunohistochemistry of CCDC106 in rat brain tissue with CCDC106 antibody at 5 μg/mL.Application
Western blot analysis of CCDC106 in human brain tissue lysate with CCDC106 antibody at (A) 0.5 and (B) 1 μg/mL.| Product Name | CCDC106 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CCDC106 Antibody: ZNF581, HSU79303, Coiled-coil domain-containing protein 106 |
| Product description | CCDC106 Antibody: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.1) Steinmetz MO, Jelesarov I, Matousek WM, et al. Molecular basis of coiled-coil formation. Proc. Natl. Acad. Sci. USA2007; 104:7062-7. |
| Immunogen | CCDC106 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human CCDC106. The immunogen is located within the last 50 amino acids of CCDC106. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| CCDC106 antibody can be used for detection of CCDC106 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CCDC106 |
|---|---|
| Alternative Names | CCDC106 Antibody: ZNF581 HSU79303 Coiled-coil domain-containing protein 106 |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine: (100%) |
Application
Immunofluorescence of CCDC106 in rat brain tissue with CCDC106 antibody at 20 μg/mL.
Application
Immunohistochemistry of CCDC106 in rat brain tissue with CCDC106 antibody at 5 μg/mL.
Application
Western blot analysis of CCDC106 in human brain tissue lysate with CCDC106 antibody at (A) 0.5 and (B) 1 μg/mL.| Positive Control | 1) Cat. No. 1303 - Human Brain Tissue Lysate |
|---|---|
| Application Notes | CCDC106 antibody can be used for detection of CCDC106 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | CCDC106 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | CCDC106 Antibody is supplied in PBS containing 0.02% sodium azide. |
