The eukaryotic cell cycle is governed by cyclin-dependent
protein kinases (CDKs) whose activities are regulated by cyclins
and CDK inhibitors. The 8 species of cyclins reported in mammals,
cyclins A through H, share a conserved amino acid sequence of about
90 residues called the cyclin box. The amino acid sequence of
cyclin G is well conserved among mammals. The nucleotide sequence
of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1,
cyclin G2 contains a C-terminal PEST protein destabilization motif,
suggesting that cyclin G2 expression is tightly regulated through
the cell cycle.1) Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Immunogen
This CCNG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the Central region of human CCNG2.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.