Application
Immunohistochemistry staining of CCR3 in tonsil, lymphocytes tissue using CCR3 Antibody.| Product Name | CCR3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CCR3, C-C chemokine receptor type 3, B-chemokine receptor, CD193, CD193 antigen, Chemokine c-c motif receptor 3, C-C chemokine receptor 3, CKR3, CC-CKR-3, CCR-3, CMKBR3, Eosinophil eotaxin receptor, Eotaxin receptor, C-C CKR-3, CC chemokine receptor 3 |
| Product description | CCR3, a Chemokine Receptor, was cloned from human eosinophils (Daugherty et al., 1996). This receptor binds specifically the chemokine eotaxin and activates eosinophil leukocytes. CCR3 also responds to a variety of beta-chemokines (CC motif) including RANTES, monocyte chemotactic proteins, and mucosae-associated epithelial chemokine (MEC). CCR3 is a key mediator of allergic reactions; activation of this receptor stimulates the production of interleukins required for activation of basophils and eosinophils (Sallusto et al., 1997). CCR3 plays a role in the progression and pathogenesis of inflammatory diseases such as asthma, multiple sclerosis, and Alzheimer's disease. This receptor also facilitates HIV-1 penetration in heart and brain. |
| Immunogen | CCR3 antibody was raised against a peptide located in the 3rd extracellular domain of CCR3 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| CCR3 antibody can be used in ELISA, and immunohistochemistry starting at 20 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CCR3 |
|---|---|
| Alternative Names | CCR3 C-C chemokine receptor type 3 B-chemokine receptor CD193 CD193 antigen Chemokine c-c motif receptor 3 C-C chemokine receptor 3 CKR3 CC-CKR-3 CCR-3 CMKBR3 Eosinophil eotaxin receptor Eotaxin receptor C-C CKR-3 CC chemokine receptor 3 |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Application
Immunohistochemistry staining of CCR3 in tonsil, lymphocytes tissue using CCR3 Antibody.| Application Notes | CCR3 antibody can be used in ELISA, and immunohistochemistry starting at 20 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | CR3 antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
