Application
Western blot analysis of extracts of various cell lines, using PTPN1 antibody.Application
Immunohistochemistry of paraffin-embedded human liver injury using PTPN1 antibody at dilution of 1:200 (400x lens).Application
Immunofluorescence analysis of MCF-7 cell using PTPN1 antibody. Blue: DAPI for nuclear staining.| Product Name | PTP1B antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to PTP1BThe protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant protein of human PTPN1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHCIHC-PWB |
| WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | protein tyrosine phosphatase non-receptor type 1 PTPN1 |
|---|---|
| Target | PTP1B |
Application
Western blot analysis of extracts of various cell lines, using PTPN1 antibody.
Application
Immunohistochemistry of paraffin-embedded human liver injury using PTPN1 antibody at dilution of 1:200 (400x lens).
Application
Immunofluorescence analysis of MCF-7 cell using PTPN1 antibody. Blue: DAPI for nuclear staining.| Application Notes | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
