Western blot analysis of CD1B using rabbit polyclonal CD1B Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CD1B gene.
This gene encodes a member of the CD1 family of
transmembrane glycoproteins, which are structurally related to the
major histocompatibility complex (MHC) proteins and form
heterodimers with beta-2-microglobulin. The CD1 proteins mediate
the presentation of primarily lipid and glycolipid antigens of self
or microbial origin to T cells. The human genome contains five CD1
family genes organized in a cluster on chromosome 1. The CD1 family
members are thought to differ in their cellular localization and
specificity for particular lipid ligands. The protein encoded by
this gene localizes to late endosomes and lysosomes via a
tyrosine-based motif in the cytoplasmic tail, and requires
vesicular acidification to bind lipid antigens. [provided by
RefSeq].1) Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Immunogen
This CD1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human CD1B.
Western blot analysis of CD1B using rabbit polyclonal CD1B Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CD1B gene.
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.