Application
Immunohistochemistry of CDIP in mouse brain tissue with CDIP antibody at 2.5 μg/mL.Application
Immunofluorescence of CDIP1 in mouse brain tissue with CDIP1 antibody at 20 μg/mL.Application
Western blot analysis of CDIP in human brain lysate with CDIP antibody at (A) 0.25 and (B) 0.5 μg/mL.| Product Name | CDIP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CDIP Antibody: I1, CDIP, LITAFL, C16orf5, Cell death-inducing p53-target protein 1, Cell death involved p53-target |
| Product description | CDIP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.1) Guimaraes DP and Hainaut P. TP53: a key gene in human cancer. Biochimie2002; 84:83-93. |
| Immunogen | CDIP antibody was raised against a 19 amino acid synthetic peptide near the center of human CDIP. The immunogen is located within amino acids 70 - 120 of CDIP. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| CDIP antibody can be used for detection of CDIP by Western blot at 0.25 - 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | C16orf5 |
|---|---|
| Alternative Names | CDIP Antibody: I1 CDIP LITAFL C16orf5 Cell death-inducing p53-target protein 1 Cell death involved p53-target |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Rat: (100%) |
Application
Immunohistochemistry of CDIP in mouse brain tissue with CDIP antibody at 2.5 μg/mL.
Application
Immunofluorescence of CDIP1 in mouse brain tissue with CDIP1 antibody at 20 μg/mL.
Application
Western blot analysis of CDIP in human brain lysate with CDIP antibody at (A) 0.25 and (B) 0.5 μg/mL.| Positive Control | 1) Cat. No. 1303 - Human Brain Tissue Lysate |
|---|---|
| Application Notes | CDIP antibody can be used for detection of CDIP by Western blot at 0.25 - 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | CDIP antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | CDIP Antibody is supplied in PBS containing 0.02% sodium azide. |
