Application
Immunohistochemistry staining of CDK5 in brain cortex tissue using CDK5 Antibody.| Product Name | CDK5 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CDK5, CDKN5, Cell division protein kinase 5, Crk6, Cyclin-dependent kinase 5, Protein kinase CDK5 splicing, PSSALRE, TPKII catalytic subunit |
| Product description | CDK5, a CDC2/CDK-type protein kinase, is associated with neuronal development. CDK5 is regulated by p35 (CDK5R1) and has been shown to phosphorylate high molecular weight neurofilaments (NEFH) and the microtubule-associated protein tau. CDK5 also associates with p25, a truncated form of p35, which accumulates in neurons in the brains of patients with Alzheimer's disease. CDK5 (-/-) mice have unique lesions in the central nervous system that are correlated with perinatal mortality. Changes in CDK5 levels have been implicated in adaptive changes in the brain related to cocaine addiction. Recently CDK5 has been shown to affect the ischemic injury of CA1 pyramidal neurons through its modulation of NMDA receptors (Wang et al. 2003). |
| Immunogen | CDK5 antibody was raised against an internal peptide of CDK5 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CDK5 |
|---|---|
| Alternative Names | CDK5 CDKN5 Cell division protein kinase 5 Crk6 Cyclin-dependent kinase 5 Protein kinase CDK5 splicing PSSALRE TPKII catalytic subunit |
Application
Immunohistochemistry staining of CDK5 in brain cortex tissue using CDK5 Antibody.| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store CDK5 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.01% sodium azide. |
