Application
Antibody used in IHC on Human kidney.Application
Antibody used in WB on Human Jurkat 2.5 ug/ml.| Product Name | CHRNB2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CHRNB2, EFNL3, nAChRB2 |
| Product description | Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.1) Hales, T.G., (2006) J. Biol. Chem. 281 (12), 8062-8071. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHRNB2. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | WB |
| CHRNB2 antibody can be used for detection of CHRNB2 by ELISA at 1:312500. CHRNB2 antibody can be used for detection of CHRNB2 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CHRNB2 |
|---|---|
| Alternative Names | CHRNB2 EFNL3 nAChRB2 |
| Molecular Weight(MW) | 57 kDa |
Application
Antibody used in IHC on Human kidney.
Application
Antibody used in WB on Human Jurkat 2.5 ug/ml.| Positive Control | 1) Cat. No. 1205 - Jurkat Cell Lysate |
|---|---|
| Application Notes | CHRNB2 antibody can be used for detection of CHRNB2 by ELISA at 1:312500. CHRNB2 antibody can be used for detection of CHRNB2 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store CHRNB2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
