Application
Immunofluorescence of CMPK2 in human lung tissue with CMPK2 antibody at 20 μg/mL.Application
Western blot analysis of CMPK2 in rat lung tissue lysate with CMPK2 antibody at 1 μg/mL| Product Name | CMPK2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CMPK2 Antibody: TYKi, TMPK2, UMP-CMPK2, UMP-CMP kinase 2, mitochondrial, Nucleoside-diphosphate kinase |
| Product description | CMPK2 Antibody: UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response1) Xu Y, Johansson M, Karlsson A. Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. J. Biol. Chem. 2008; 283:1563-71. |
| Immunogen | CMPK2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human CMPK2. The immunogen is located within amino acids 370 - 420 of CMPK2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFWB |
| CMPK2 antibody can be used for detection of CMPK2 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CMPK2 |
|---|---|
| Alternative Names | CMPK2 Antibody: TYKi TMPK2 UMP-CMPK2 UMP-CMP kinase 2 mitochondrial Nucleoside-diphosphate kinase |
| Molecular Weight(MW) | 49 kDa |
| Sequence Similarities | 2) Cat. No. 10-101 - Human Lung Tissue Slide |
| Tissue Specificity | Multiple isoforms of CMPK2 are known to exist. |
Application
Immunofluorescence of CMPK2 in human lung tissue with CMPK2 antibody at 20 μg/mL.
Application
Western blot analysis of CMPK2 in rat lung tissue lysate with CMPK2 antibody at 1 μg/mL| Positive Control | 1) Cat. No. 1462 - Rat Lung Tissue Lysate |
|---|---|
| Application Notes | CMPK2 antibody can be used for detection of CMPK2 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | CMPK2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | CMPK2 Antibody is supplied in PBS containing 0.02% sodium azide. |
