Coronin-2A, IR10, WD repeat-containing protein 2, CORO2A, IR10, WDR2
Product description
This gene encodes a member of the WD repeat protein
family. WD repeats are minimally conserved regions of approximately
40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
which may facilitate formation of heterotrimeric or multiprotein
complexes. Members of this family are involved in a variety of
cellular processes, including cell cycle progression, signal
transduction, apoptosis, and gene regulation. This protein contains
5 WD repeats, and has a structural similarity with actin-binding
proteins: the D. discoideum coronin and the human p57 protein,
suggesting that this protein may also be an actin-binding protein
that regulates cell motility. Alternative splicing of this gene
generates 2 transcript variants.1) Jin, Y., et al. Nat. Genet. 42(7):576-578(2010)
Immunogen
This CORO2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human CORO2A.
Western blot analysis in CEM cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.