Application
Western blot analysis of CRB1 in human small intestine Tissue lysate with CRB1 antibody at 1 μg/mL.| Product Name | CRB1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CRB1 Antibody: LCA8, RP12, Protein crumbs homolog 1 |
| Product description | CRB1 Antibody: CRB1 (Crumbs homolog 1) plays a role in photoreceptor morphogenesis in the retina. It may maintain cell polarization and adhesion. CRB1 is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. The first identified human homolog, CRB1, is expressed in retina and some parts of the brain, leaving room for another homolog to function in epithelial tissues. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis.1) Van de Pavert SA, Kantardzhieva A, Malysheva A, et al. Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J. Cell Sci. 2004; 117:4169-77. |
| Immunogen | Rabbit polyclonal CRB1 antibody was raised against an 18 amino acid peptide near the center of human CRB1. The immunogen is located within amino acids 780 - 830 of CRB1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| CRB1 antibody can be used for detection of CRB1 by Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CRB1 |
|---|---|
| Alternative Names | CRB1 Antibody: LCA8 RP12 Protein crumbs homolog 1 |
| Molecular Weight(MW) | Predicted: 142 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Mouse: (82%) |
| Tissue Specificity | Alternatively spliced transcript variants have been observed. CRB1 antibody i spredicted to not cross-react with CRB2. |
| Entrez Gene | 23418 |
|---|---|
| Protein Accession | NP_001180569 |
Application
Western blot analysis of CRB1 in human small intestine Tissue lysate with CRB1 antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1308 - Human Small Intestine Tissue Lysate |
|---|---|
| Application Notes | CRB1 antibody can be used for detection of CRB1 by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | CRB1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | CRB1 Antibody is supplied in PBS containing 0.02% sodium azide. |
