Application
Western blot analysis of CRIM2 in Jurkat cell lysate with CRIM2 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | CRIM2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CRIM2 Antibody: KCP1, CRIM2, NET67, KCP1, Cysteine-rich BMP regulator 2, CRIM-2 |
| Product description | CRIM2 Antibody: CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-β1, suppressing activin- and TGF-β1-dependent transcription.1) Lin J, Patel SR, Cheng X, et al. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat. Med. 2005; 11:387-93 |
| Immunogen | CRIM2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2. The immunogen is located within amino acids 1320 - 1370 of CRIM2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| CRIM2 antibody can be used for detection of CRIM2 by Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KCP |
|---|---|
| Alternative Names | CRIM2 Antibody: KCP1 CRIM2 NET67 KCP1 Cysteine-rich BMP regulator 2 CRIM-2 |
| Tissue Specificity | At least two isoforms of CRIM2 are known to exist; this antibody will only detect the larger isoform. CRIM2 antibody is predicted to not cross-react with CRIM1. |
| Entrez Gene | 375616 |
|---|---|
| Protein Accession | NP_001129386 |
Application
Western blot analysis of CRIM2 in Jurkat cell lysate with CRIM2 antibody at (A) 1 and (B) 2 μg/mL.| Positive Control | 1) Cat. No. 1205 - Jurkat Cell Lysate |
|---|---|
| Application Notes | CRIM2 antibody can be used for detection of CRIM2 by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | CRIM2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | CRIM2 Antibody is supplied in PBS containing 0.02% sodium azide. |
