Application
Immunohistochemistry staining of Cyclin T1 in skin tissue using Cyclin T1 Antibody.| Product Name | Cyclin T1 Antibody |
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| Antibody Type | Primary Antibodies |
| Product description | Cyclin T1, together with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the human immunodeficiency virus type 1 (HIV-1) transactivator Tat. Tat stimulates human HIV-1 viral transcription elongation. This suggests that cyclin T1/cdk9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation. Cyclin T1/cdk9(PITALRE) is shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb. P-TEFb facilitates transcription by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. The cdk9(PITALRE) activity and cyclin T1 are essential for activation of transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev. Cyclin T1 is an exceptionally large cyclin and is therefore a candidate for interactions with regulatory proteins. |
| Immunogen | Cyclin T1 antibody was raised against amino acids 29 - 37 of Cyclin T1 (Human) near internal region. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCIPWB |
| Cyclin T1 antibody can be used in Western Blot, immunohistochemistry starting at 5 μg/mL, and immunoprecipitation. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Sterile Filtration |
| Gene Symbol | CCNT1 |
|---|---|
| Alternative Names | CCNT1 CCNT CDK9-associated C-type protein Cyclin T1b CYCT1 Cyclin T1 HIVE1 Cyclin C-related protein Cyclin-T Cyclin-T1 |
Application
Immunohistochemistry staining of Cyclin T1 in skin tissue using Cyclin T1 Antibody.| Application Notes | Cyclin T1 antibody can be used in Western Blot, immunohistochemistry starting at 5 μg/mL, and immunoprecipitation. |
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| Form | Liquid |
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| Storage Instructions | Store Cyclin T1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
