This gene is one of two genes which encode a protein
similar to the Drosophila protein dachshund, a transcription factor
involved in cell fate determination in the eye, limb and genital
disc of the fly. The encoded protein contains two characteristic
dachshund domains: an N-terminal domain responsible for DNA binding
and a C-terminal domain responsible for protein-protein
interactions. This gene is located on the X chromosome and is
subject to inactivation by DNA methylation. The encoded protein may
be involved in regulation of organogenesis and myogenesis, and may
play a role in premature ovarian failure. Multiple transcript
variants encoding different isoforms have been found for this gene.1) Bailey, S.D., et al. Diabetes Care (2010) In press :
Immunogen
This DACH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-173 amino acids from the N-terminal region of human DACH2.
Western blot analysis in HepG2,Jurkat cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.